'%20d='M364.9%20143.2v98.9l-1.4%201.2-165.6%20140.4%2035.7%2029.7v-34.2l1.4-1.2%20123.4-105.4%206.5-5.6v37l-1.3%201.2-99.7%2085.8v84.7l-6.6-5.7-97-83.1-3.6-3%203.5-3%20174.4-150.6v-25.1L153.7%20360.5l-6.6%205.7v-98.9l1.4-1.2%20161.6-138-35.7-29.7v34.4L273%20134%20153.7%20236.7l-6.6%205.7v-37l1.3-1.2%2097-83.2V36.3L252%2042l97.1%2083.1%203.6%203-3.6%203-171.7%20147.7V304l106.2-90.6%2056.4-48.8%2018.3-15.7z'%20/%3e%3c/svg%3e)
GenomicsIn preparation
VEP, and whata variant actually does
The Ensembl Variant Effect Predictor.Consequences on genes, transcripts and proteins.
Not on the hub yet The image and its definition are being built and verified.
01Pick a machinecores, memory and a rate per hour
02Set it up oncekept on the volume between runs
03Run it, then stopstopped when the work is done
The application
A variant,and its consequence
A position and a change is not an answer. This turns it into one.
Every transcript
One consequence per variant per transcript, not one per gene.
Cache or database
It runs against a local cache, or the Ensembl databases live.
How bad it looks
SIFT and PolyPhen scores come along with the coding changes.
The status
Being built,and verified
When the image and its definition are done, it deploys by name like the rest.
Machines that fit it
Ensembl VEP has no fixed ask, so these start from 2 cores and 4 GB. Cheapest first.
Run Ensembl VEP on your own machinePick a machine that meets it, and it opens about a minute after you ask.